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Table 4 Direct coupling terms for specific amino acid variants at covarying positions within the HIV-1 integrase

From: Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Position i Amino acid α Position j Amino acid β eij (α, β) Time trend Minor INSTI resistance mutation INSTI-selected mutation
10 D 122 I 0.0683    *
10 E 122 I −0.0753    *
11 D 119 S −0.0940 *   
11 D 154 I −0.0527 *   *
11 D 154 M 0.0335 *   
11 E 119 S 0.0909 *   
11 E 154 I 0.0577 *   *
11 E 154 M −0.0368 *   
17 N 124 A 0.0690   *  
17 S 124 A −0.0598   *  
23 A 201 I −0.0490    *
23 A 201 V 0.0525    *
23 V 201 I 0.0432    *
23 V 201 V −0.0443    *
31 I 154 I −0.0438    *
31 V 154 I 0.0352    *
39 C 154 I −0.0329    *
39 C 201 I 0.0776    *
39 C 201 V −0.0725    *
39 S 154 I 0.0384    *
39 S 201 I −0.0859    *
39 S 201 V 0.0828    *
72 I 265 A 0.0587 *   
72 I 265 V −0.0612 *   
72 V 265 A −0.0622 *   
72 V 265 V 0.0676 *   
101 I 111 K −0.0743    *
101 I 111 T 0.0334    *
101 I 154 I −0.0462 *   *
101 I 154 M 0.0645 *   *
101 L 154 I 0.0606 *   *
101 L 154 M −0.0695 *   
112 A 124 A 0.0205   *  
112 I 124 A 0.0205   *  
112 I 201 I 0.0482    *
112 I 201 V −0.0538    *
112 T 124 A −0.0447   *  
112 T 201 I −0.0483    *
112 T 201 V 0.0490    *
119 G 122 I 0.0576    *
119 P 122 I 0.1303    *
119 S 122 I −0.1695 *   *
119 T 122 I −0.0194    *
124 A 125 T 0.0266   *  
124 A 125 V −0.0288   *  
124 A 211 K −0.0568   *  
124 A 211 R 0.0263   *  
124 A 211 T 0.0294   *  
124 S 125 A 0.0244    *
124 T 125 A −0.0205    *
154 I 165 I 0.0893 *   *
154 I 165 V −0.0976 *   *
154 I 256 D 0.0333    *
154 I 256 E −0.0369 *   *
154 I 265 A 0.0520 *   *
154 I 265 V −0.0484 *   *
154 M 165 I −0.1011 *   
154 M 165 V 0.1118 *   
154 M 256 E 0.0525 *   
154 M 265 A −0.0496 *   
154 M 265 V 0.0482 *   
157 Q 160 K −0.0632   *  
157 Q 160 Q 0.0649   *  
201 I 256 D 0.0623    *
201 I 256 E −0.0611 *   *
201 I 265 A 0.0484 *   *
201 I 265 V −0.0466 *   *
201 V 256 E 0.0604 *   
201 V 265 A −0.0535 *   
201 V 265 V 0.0547 *   
  1. Couplings with time-trending amino acid variants, minor INSTI resistance mutations, and INSTI-selected mutations are indicated by a star