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Table 2 Age specific attribution of precancerous cervical lesions to vaccine HPV genotypes attending three estimate methods

From: Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain

  

CIN2

CIN3-CIS

CIN2–3

Method

Women age (years)

HPV 16/18 (%)

HPV 31/33/45/52/58 (%)

p

HPV 16/18 (%)

HPV 31/33/45/52/58 (%)

p

HPV 16/18 (%)

HPV 31/33/45/52/58 (%)

p

Minimum estimate

18–34

64

25

 

71

14

*

69

17

*

35–44

52

39

 

68

13

 

62

22

*

≥45

33

33

 

52

24

 

45

27

*

p-trend

      

*

  

Proportional attribution

18–34

53

29

*

74

13

*

66

19

*

35–44

48

41

*

64

16

*

59

24

*

≥45

48

26

 

44

28

*

46

27

*

p-trend

      

*

*

 

Hierarchical attribution

18–34

63

23

*

78

12

*

72

16

*

35–44

51

40

*

66

19

*

62

26

*

≥45

50

25

 

45

32

*

47

29

*

p-trend

      

*

*

 
  1. *p-trend < 0.05 for each HPV group prevalence decrease with increasing age
  2. *p < 0.05 for absolute additional fraction of cervical lesions attributable to HPV genotypes targeted by nonavalent vaccine compared to the fraction attributable to those targeted by bi/quadrivalent vaccines