Characteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Region, China

Table 2 Specific sites analysis of two H13N8 virus proteins

Protein	Mutation sites (aa)	Viruses		Possible function
Protein	Mutation sites (aa)	A/Environment/Qinghai Lake/013/2012	A/Environment/Qinghai Lake/166/2012	Possible function
HA	T135 V	V	V	Receptor binding specificity relative 130 bp
	T136S	S	S	Receptor binding specificity relative 130 bp
	V186 N	V	V	Human receptor binding preference of H13 subtype
	E190D	E	E	Human receptor binding preference
	Q226L	Q	Q	Human receptor binding shift of H2,3,5 subtypes
	G228S	S	S	Human receptor binding shift of H2,3,5 subtypes
		PAISNR↓GLF	PAISNR↓GLF	HA cleavage site
PB2	E627K	E	E	Mammalian adaption mutations
PB2	D701N	D	D	Mammalian adaption mutations
M1	N30D	D	D	Increase pathogenicity of H5N1 to mice
M1	T215A	A	A	Increase pathogenicity of H5N1 to mice
M2	S31 N	S	S	Adamantine resistance mutation
NA	E119V	E	E	Neuraminidase inhibitor resistance mutation
	R292K	R	R
	R152V	R	R
	H274Y	H	H

*specific sites related to virus pathogenicity, virulence which have been published by other studies

ISSN: 1743-422X