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Fig. 3 | Virology Journal

Fig. 3

From: Comparison of the protective efficacy between single and combination of recombinant adenoviruses expressing complete and truncated glycoprotein, and nucleoprotein of the pathogenic street rabies virus in mice

Fig. 3

Survival rates of mice immunized with recombinant adenoviruses expressing RABV G and N protein after RABV CVS-N2c challenge. Mice in each group were inoculated with 0.2 mL of each virus (Ad-0910G and Ad-0910Gsped) or mixed virus (Ad-0910G + Ad-0910 N and Ad-0910Gsped + Ad-0910 N) by the intramuscular route. Mice in the control group were inoculated with an equal volume of PBS. Five immunized mice from each group were challenged intramuscularly (IM) with 30 μL of CVS-N2c (25 LD50/0.03 mL) 21 days following inoculation of recombinant adenoviruses (a). The remaining five mice in each group were challenged via the intracranial (IC) route (b). After challenge, the survival of mice was checked daily for 3 weeks

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