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Table 2 Virological and Biochemical Responses During ETV Rescue Therapy

From: Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants

Response rtA181 group (n = 31) rtA181 + rtN236 group (n = 25) P value
Virological
HBV DNA Reduction (log10 IU/mL)
 6th Month (Mean ± SD) 3.18 ± 1.92 3.52 ± 2.04 0.520
 12th Month (Mean ± SD) 3.59 ± 1.85 3.76 ± 2.15 0.756
undectectable
 6th Month (No. %) 24/31 (77.4%) 19/25 (76.0%) 0.900
 12th Month (No. %) 27/31 (87.1%) 22/25 (88.0%) 0.919
HBeAg loss
 6th Month (No. %) 3/24 (1.3%) 1/18 (5.6%) 0.448
 12th Month (No. %) 5/24 (20.8%) 2/18 (11.1%) 0.403
Biochemical
Total bilirubin level (μmol/L)
 6th Month (Mean ± SD) 16.0 ± 10.0 14.3 ± 4.7 0.440
 12th Month (Mean ± SD) 16.3 ± 8.9 14.4 ± 3.7 0.329
Normalization of serum Tbil
 6th Month (No. %) 26/31 (%) 22/25 (72.0%) 0.661
 12th Month (No. %) 24/31 (89.6%) 22/25 (88.0%) 0.304
ALT (U/L)
 6th Month (Mean ± SD) 38.3 ± 20.6 37.7 ± 15.0 0.903
 12th Month (Mean ± SD) 37.2 ± 18.4 34.3 ± 12.2 0.500
Normalization of serum ALT
 6th Month (No. %) 23/31 (74.2%) 21/25 (84.0%) 0.374
 12th Month (No. %) 28/31 (90.3%) 20/25 (80.0%) 0.272