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Table 1 Reported Cases of HSVE after Neurosurgery

From: Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature

Author, Year Age Previous HSVE History Diagnosis Procedure Time to Symptoms Etiology Steroids Treatment (Time to treatment) Outcome
Fearnside [6], 1972 41 No Pituitary adenoma Craniotomy POD 4 HSV Yes Idoxuridine IV (POD 8) Death
Fearnside [6], 1972 11 No Pituitary adenoma Craniotomy POD 8 HSV Yes None Death
Perry [19], 1998 64 No Cranio-pharyngioma Craniotomy POD 2 HSV-2 Yes Acyclovir IV (POD >14) Cognitive and visual sequelae
Spuler [24], 1999 78 No Parasagittal meningioma Craniotomy POD 10 HSV-1 Yes None Death
Bourgeois [5], 1999 8 Yes Refractory epilepsy Craniotomy POD 6 HSV-1 NA Acyclovir IV (timing not shown) Complete recovery
Molloy [18], 2000 22 No Medullo-bastoma Craniotomy POD >21 HSV Yes None Death
Lellouch [10], 2000 8 Yes Refractory epilepsy Craniotomy POD 6 HSV-1 NA Aciclovir (timing not shown) Speech impairment
Sheleg [23], 2001 28 No Gliobalstoma multiforme Craniotomy POD 2 HSV-1 Yes None Death
Aldea [11], 2003 28 Possible Anaplasic oligo-dendroglioma Craniotomy POD 7 HSV-1 Yes Acyclovir IV (POD 9) Complete recovery
Filipo [12], 2005 33 No Acoustic neuroma Mastoidectomy POD 2 HSV-1 Yes Acyclovir IV (POD 11) Complete recovery
Ploner [20], 2005 47 No Meningioma Craniotomy POD 10 HSV Yes Acyclovir IV (POD 13) Apathic state
Kwon [9], 2008 13 No Cranio-pharyngioma Craniotomy POD 15 HSV Yes Acyclovir IV (POD 22) Speech and motor impairment
Jalloh [14], 2009 44 No Acoustic neuroma Mastoidectomy POD 1 HSV-1 NA Acyclovir IV (POD 11) Complete recovery
Ihekwaba [13], 2009 35 No Type 1 Chiari malformation Sub-occipital craniectomy POD 14 HSV-2 Yes Acyclovir IV (POD >21) Complete recovery
Gong [7], 2010 2 Yes Refractory epilepsy Craniotomy POD 5 HSV-1 Yes Acyclovir IV (POD 5) Complete recovery
Lund [16], 2011 19 Yes Frontal lobe epilepsy Craniotomy POD 10 HSV NA Acyclovir (POD 20) Death
Raper [22], 2011 65 No Ependymoma Laminectomy POD 5 HSV-1 Yes Acyclovir IV (POD 8) Complete recovery
Mallory [17], 2012 49 No Acoustic neuroma Craniotomy POD 10 HSV-1 Yes Valacyclovir PO (POD 10) Complete recovery
Uda [25], 2013 20 Yes Medial temporal lobe epilepsy Craniotomy POD 11 HSV NA Acyclovir IV (POD 11) Complete recovery
Kim [8], 2013 11 Yes Refractory epilepsy Craniotomy POD 5 HSV-1 NA Acyclovir IV (POD 10) Complete recovery
Prim [21], 2013 78 No Trigeminal neuralgia Rhizothomy POD 1 HSV-1 NA Acyclovir IV (POD 17) Neuro-psychiatric sequelae
Vik-Mo [26], 2014 25 Possible Medial temporal lobe epilepsy Craniotomy POD 3 HSV-2 NA Acyclovir IV (POD 18) Speech impairment
Presti [15], 2015 17 Yes Refractory epilepsy Craniotomy POD 6 No virus found Yes Acyclovir IV (POD 11) Motor and behavioral sequelae
Jaques, case 1 2015 24 No Epidermoid cyst Craniotomy POD 8 HSV-1 Yes Acyclovir (POD 11) Complete recovery
Jaques, case 2, 2015 53 No Cranio-pharyngioma Craniotomy POD 18 HSV-2 Yes Acyclovir IV (POD 19) Complete recovery
Jaques, case 3, 2015 12 Yes Refractory epilepsy Craniotomy POD 11 HSV-1 No Acyclovir IV(POD 14) Mild left hemiparesy