Fig. 1

a Laboratory-bred cotton rats. b Distribution range of S. hispidus (map adapted from IUCN Red List of Threatened Species, http://www.iucnredlist.org). c Light microscopy image of subclone ShispREC.B-6. d Immunofluorescence staining for the following epithelial cell markers: pan-cytokeratin (Pan-CK) (red) and zonula occludens-1 (ZO-1) (green). Nuclei were counterstained with DAPI (blue)