Table 2 Summary of statistics of positions significant in the comparison between the hydropathy index of R4X4 and R5 sequences

 Rank

HXB2 residue

Position^a

p (U-test)^b

p (Q_FD = .05)^c

p (Q_FD = .1)^c

Location

  1

L

619

.00023

.00086

.0017

Loop-HR2

  2

A

667

.00033

.0017

.0034

MPER

  3

S

640

.00064

.0026

.0052

HR2

  4

R

841

.0009

.0034

.0068

LLP-1

  5

N

636

.0027

.0043

.0086

HR2

  6

L

641

.0030

.0052

.0104

HR2

  7

I

756

.0040

.0060

.0120

MSD3

  8

M

535

.0061

.0069

.0138

Fusion peptide

  9

E

662

.0067

.0078

.0156

MPER

  10

T

723

.0075

.0086

.0172

Minor ectodomain

  11

I

746

.0135

.0095

.0190

Minor ectodomain-MSD3

  12

Q

658

.0164

.0103

.0206

HR2

 Rank

HXB2 residue

Position

p (X ²)^b

p (Q_FD = .05)^c

p (Q_FD = .10)^c

  1

A

667

.00002

.00086

.0017

MPER

  2

L

602

.00013

.0017

.0034

Loop

  3

L

641

.00019

.0026

.0052

HR2

  4

L

619

.00022

.0034

.0068

Loop-HR2

  5

E

662

.0076

.0043

.0086

MPER

  6

V

778

.0080

.0052

.0104

LLP-2