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Table 2 Summary of statistics of positions significant in the comparison between the hydropathy index of R4X4 and R5 sequences

From: Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

Mann–Whitney U test
 Rank HXB2 residue Positiona p (U-test)b p (QFD = .05)c p (QFD = .1)c Location
  1 L 619 .00023 .00086 .0017 Loop-HR2
  2 A 667 .00033 .0017 .0034 MPER
  3 S 640 .00064 .0026 .0052 HR2
  4 R 841 .0009 .0034 .0068 LLP-1
  5 N 636 .0027 .0043 .0086 HR2
  6 L 641 .0030 .0052 .0104 HR2
  7 I 756 .0040 .0060 .0120 MSD3
  8 M 535 .0061 .0069 .0138 Fusion peptide
  9 E 662 .0067 .0078 .0156 MPER
  10 T 723 .0075 .0086 .0172 Minor ectodomain
  11 I 746 .0135 .0095 .0190 Minor ectodomain-MSD3
  12 Q 658 .0164 .0103 .0206 HR2
χ2 test
 Rank HXB2 residue Position p (X 2)b p (QFD = .05)c p (QFD = .10)c  
  1 A 667 .00002 .00086 .0017 MPER
  2 L 602 .00013 .0017 .0034 Loop
  3 L 641 .00019 .0026 .0052 HR2
  4 L 619 .00022 .0034 .0068 Loop-HR2
  5 E 662 .0076 .0043 .0086 MPER
  6 V 778 .0080 .0052 .0104 LLP-2
  1. aResidue number is based on the sequence of HXB2 gp120
  2. bBold characters indicate positions with significant p values using QFD = .05. Normal characters indicate aditional positions with significant p values using QFD = .1
  3. cBenjamini-Hochberg critical p values