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Table 2 Different types of ALI cultures used in coronavirus studies

From: Coronaviruses and the human airway: a universal system for virus-host interaction studies

Cell types

Origin

HCoVs

Features

References

Primary bronchial

Trachea, Bronchus

All HCoVs

Differentiated pseudostratified epithelium, many cell types

[56, 57]

Calu-3

Sub-mucosal glands (adenocarcinoma)

MERS-CoV, SARS-CoV

Single or polarized epithelium, one cell type

[109, 110]

Primary alveolar

Alveoli

MERS-CoV, SARS-CoV, HCoV-HKU1

Differentiated squamous epithelium, two cell types

[79, 80, 111]

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Virology Journal

ISSN: 1743-422X