Table 3 Ratio of 70R to 70Q/H during treatment determined by cloning and sequencing
Patients | 0 W | 2 W | 4 W | 8 W | 12 W | 24 W | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
70R | Codon 70 | 70R | Codon 70 | 70R | Codon 70 | 70R | Codon 70 | 70R | Codon 70 | 70R | Codon 70 | |
A1/B1 | 81.3 % | 16CGG/4CAG | 79.9 % | 15CGG/4CAG/1 N.D. | 83.4 % | 16CGG/2CAG/2 N.D. | / | / | / | / | / | / |
A2/B2 | 97.6 % | 14CGA/5CGG/1CAG | 97.8 % | 13CGA/4CGG/3 N.D. | 97.2 % | 14CGA/5CGG/1 N.D. | 96.8 % | 14CGA/4CGG/2 N.D. | 97.3 % | 15CGA/5CGG | 97.4 % | 15CGA/3CGG/1CAG/1 N.D. |
A3/B3 | 3.7 % | 18CAG/2 N.D. | 2.4 % | 17CAG/1CGT/2 N.D. | 3.4 % | 20CAG | 4.7 % | 19CAG/1CGT | 3.8 % | 18CAG/1CGT/1 N.D. | 2.4 % | 19CAG/1 N.D. |
A4/B4 | 9.7 % | 2CGG/18CAA | / | / | / | / | / | / | / | / | 6.2 % | 1CGG/18CAA/1 N.D. |
A5/B5 | 98.5 % | 4CGG/14CGA/1CAG/1 N.D. | / | / | / | / | / | / | / | / | 99.0 % | 4CGG/13CGA/3 N.D. |
A6/B6 | 89.9 % | 18CGG/2CAG | 82.5 % | 17CGG/3CAG | / | / | / | / | / | / | / | / |
A7/B7 | 55.5 % | 11CGG/8CAG/1 N.D. | 65.6 % | 13CGG/7CAG | 69.4 % | 13CGG/6CAG/1 N.D. | / | / | / | / | / | / |