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Table 3 Ratio of 70R to 70Q/H during treatment determined by cloning and sequencing

From: Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

Patients 0 W 2 W 4 W 8 W 12 W 24 W
70R Codon 70 70R Codon 70 70R Codon 70 70R Codon 70 70R Codon 70 70R Codon 70
A1/B1 81.3 % 16CGG/4CAG 79.9 % 15CGG/4CAG/1 N.D. 83.4 % 16CGG/2CAG/2 N.D. / / / / / /
A2/B2 97.6 % 14CGA/5CGG/1CAG 97.8 % 13CGA/4CGG/3 N.D. 97.2 % 14CGA/5CGG/1 N.D. 96.8 % 14CGA/4CGG/2 N.D. 97.3 % 15CGA/5CGG 97.4 % 15CGA/3CGG/1CAG/1 N.D.
A3/B3 3.7 % 18CAG/2 N.D. 2.4 % 17CAG/1CGT/2 N.D. 3.4 % 20CAG 4.7 % 19CAG/1CGT 3.8 % 18CAG/1CGT/1 N.D. 2.4 % 19CAG/1 N.D.
A4/B4 9.7 % 2CGG/18CAA / / / / / / / / 6.2 % 1CGG/18CAA/1 N.D.
A5/B5 98.5 % 4CGG/14CGA/1CAG/1 N.D. / / / / / / / / 99.0 % 4CGG/13CGA/3 N.D.
A6/B6 89.9 % 18CGG/2CAG 82.5 % 17CGG/3CAG / / / / / / / /
A7/B7 55.5 % 11CGG/8CAG/1 N.D. 65.6 % 13CGG/7CAG 69.4 % 13CGG/6CAG/1 N.D. / / / / / /
  1. N.D., no data available due to sequencing failure