Tackling dengue fever: Current status and challenges

Table 2 Current status of dengue vaccine development

No	Strategy	Developer (s)	Current status
1	Live attenuated yellow fever 17D/DENV chimeric vaccine	Sanofi-Pasteur	Phase 3 trials with a tetravalent formulation in DENV endemic countries
2	PDK cell-passaged, live attenuated vaccine	WRAIR/GSK	Phase 2 trials with a tetravalent formulation in endemic countries
3	Live attenuated DENV Delta-30 mutation and intertypic DENV chimeric vaccines	NIH/Johns Hopkins	Phase 1/2 trials with monovalent formulations completed; tetravalent
3		NIH/Johns Hopkins	phase 1 initiated
4	Dengue prM-E DNA vaccine	NMRC	Phase 1 with monovalent vaccine completed
5	Recombinant 80 % E subunit antigen vaccine	Hawaii Biotech/Merck	Phase 1 with monovalent vaccine initiated
6	Purified inactivated vaccine	WRAIR	Phase 1 with monovalent vaccine initiated
7	Live attenuated chimeric DENV vaccine	CDC	Phase 1 with monovalent vaccine initiated

Abbreviations: PDK, primary dog kidney cells; WRAIR, Walter Reed Army Institute of Research; GSK, GlaxoSmithKline Biologicals; NIH, National Institutes of Health; prM-E, premembrane-envelope; NMRC, Naval Medical Research Center; CDC, Centers of Disease Control and Prevention

ISSN: 1743-422X