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Table 3 Comparison of the effect of changes at conserved residues in the octapeptide of MVEV and DENV-4 on NS1-2A cleavage

From: Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction

Octapeptide residue

Substitution

Cleavage efficiency

MVEVa

DENV-4b

P1 Ala

Ser

53 ± 2

10 ± 3

 

Leu

6 ± 1

4 ± 4

 

Phe

7 ± 0

0

 

Arg

7 ± 0

5 ± 5

 

Asp

10 ± 1

3 ± 2

P3 Val

Leu

23 ± 3

4 ± 3

 

Gly

83 ± 1

10 ± 4

 

Lys

14 ± 2

1 ± 2

P5 Ser

Ala

83 ± 2

100 ± 11

 

Arg

13 ± 4

8 ± 3

 

Pro

67 ± 2

132 ± 4

P7 Val

Gly

60 ± 3

1 ± 1

 

Arg

11 ± 4

1 ± 1

P8 Leu or Met

Glu

9 ± 0

2 ± 1

 

Lys

8 ± 3

2 ± 3

  1. aData from Table 1
  2. bData from reference [6]
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Virology Journal

ISSN: 1743-422X