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Table 3 Comparison of the effect of changes at conserved residues in the octapeptide of MVEV and DENV-4 on NS1-2A cleavage

From: Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction

Octapeptide residue Substitution Cleavage efficiency
MVEVa DENV-4b
P1 Ala Ser 53 ± 2 10 ± 3
  Leu 6 ± 1 4 ± 4
  Phe 7 ± 0 0
  Arg 7 ± 0 5 ± 5
  Asp 10 ± 1 3 ± 2
P3 Val Leu 23 ± 3 4 ± 3
  Gly 83 ± 1 10 ± 4
  Lys 14 ± 2 1 ± 2
P5 Ser Ala 83 ± 2 100 ± 11
  Arg 13 ± 4 8 ± 3
  Pro 67 ± 2 132 ± 4
P7 Val Gly 60 ± 3 1 ± 1
  Arg 11 ± 4 1 ± 1
P8 Leu or Met Glu 9 ± 0 2 ± 1
  Lys 8 ± 3 2 ± 3
  1. aData from Table 1
  2. bData from reference [6]