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Fig. 4 | Virology Journal

Fig. 4

From: Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway

Fig. 4

PEDV inhibits IPS-1- and RIG-I-induced IFN-β production. PEDV-infected IECs were cotransfected with the IFN-β promoter luciferase reporter and IPS-1 (a) or RIG-I (b) expression plasmids or vector for 24 h. Cells were then retransfected with poly (I:C) for 12 h. Cells were harvested and luciferase activity was analyzed using a dual-luciferase assay. All data are expressed as means ± SD of 3 independent experiments. **p < 0.01 compared with PEDV-infected, expression plasmids or vector-transfected control

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