Patient-derived hepatitis C virus inhibits CD4 + but not CD8 + T lymphocyte proliferation in primary T cells

Table 1 Virological characteristics of individuals with CHC providing plasma serving as HCV inocula and HCV RNA loads in T cells infected with these inocula

Inoculum	Case/Sex	HCV genotype	Plasma HCV RNA^a (vge/mL)	HCV RNA load in cells
				1 d.p.i.		7 d.p.i.		10 d.p.i.
				Positive strand^a (vge/μg RNA)	Negative strand^b	Positive strand^a (vge/μg RNA)	Negative strand^b	Positive strand^a (vge/μg RNA)	Negative strand^b
CHC-1	C26/F	1a/1b	1.1 × 10⁶	8777	neg	1290	pos	1010	pos
CHC-2	C33/M	3a	2 × 10⁴	746	neg	204	neg	neg	NT
CHC-3	N28/F	2b	2.4 × 10⁶	<50	NT	<50	NT	<50	NT

dpi days post-infection, F female, M male, NT not tested, pos positive, neg negative
^aQuantified by in house real-time RT-PCR
^bDetermined by the strand-specific RT-PCR/NAH

ISSN: 1743-422X