Table 4 Sensitivity and specificity of single and combined mutations for prediction of ACLF
Mutation site | Mutation status | No. of ACLF patients | No. of patients without ACLF | Sensitivity % (95 % CI) | Specificity, % (95 % CI) | PPV | NPV |
|---|---|---|---|---|---|---|---|
T1753V | pos | 392 | 397 | 29.3 (26.9 to 31.9) | 83.3 (81.8 to 84.8) | 49.7 (46.1 to 53.2) | 67.8 (66.0 to 69.5) |
neg | 945 | 1986 | |||||
A1762T | pos | 872 | 1207 | 74.5 (71.9 to 76.9) | 45.8 (43.7 to 47.9) | 41.9 (39.8 to 44.1) | 77.3 (75.0 to 80.0) |
neg | 299 | 1019 | |||||
G1764A | pos | 921 | 228 | 43.0 (40.9 to 45.1) | 80.6 (78.3 to 82.9) | 80.1 (77.7 to 82.4) | 43.7 (41.6 to 45.9) |
neg | 1221 | 949 | |||||
A1762T/G1764A | pos | 678 | 825 | 51.6 (48.9 to 54.4) | 63.1 (61.1 to 65.1) | 45.1 (42.6 to 47.7) | 69.0 (66.9 to 71.0) |
neg | 635 | 1412 | |||||
C1766T | pos | 113 | 118 | 10.3 (8.6 to 12.2) | 94.1 (93.0 to 95.1) | 48.9 (42.3 to 55.6) | 65.8 (64.0 to 67.5) |
neg | 986 | 1897 | |||||
T1768A | pos | 80 | 64 | 6.9 (5.5 to 8.5) | 96.9 (96.1 to 97.6) | 55.6 (47.1 to 63.8) | 65.1 (63.4 to 66.8) |
neg | 1083 | 2020 | |||||
A1846T | pos | 304 | 251 | 54.7 (50.4 to 58.9) | 72.8 (69.8 to 75.6) | 54.8 (50.5 to 59.0) | 72.7 (69.7 to 75.5) |
neg | 252 | 670 | |||||
G1896A | pos | 1025 | 1254 | 52.6 (50.4 to 54.8) | 65.6 (64.0 to 67.1) | 45.0 (42.9 to 47.0) | 72.1 (70.5 to 73.6) |
neg | 924 | 2386 | |||||
G1899A | pos | 323 | 182 | 22.2 (20.1 to 24.4) | 92.7 (91.7 to 93.7) | 64.0 (59.6 to 68.2) | 67.2 (65.6 to 68.8) |
neg | 1133 | 2325 | |||||
G1896A/A1762T/G1764A | pos | 107 | 135 | 17.6 (14.7 to 20.9) | 87.4 (85.2 to 89.3) | 44.2 (37.9 to 50.7) | 65.1 (62.6 to 67.6) |
neg | 500 | 934 |