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Table 3 Cytokine levels in the sera / supernatants of stimulated-splenocytes and expression of corresponding genes in the spleens of non-pregnant and pregnant immunized mice at different time points

From: Enhanced humoral response in pregnant mice immunized with liposome encapsulated recombinant neutralizing epitope protein of Hepatitis- E virus

Category and time after the dose Serum cytokines (pg/ml) Gene expression spleen (fold change) Splenocytes (rNEp-stimulated , pg/ml)
IL-2 IL-4 IFN-γ IL-2 IL-4 IFN-γ IL-2 IL-4 IFN-γ
NPR 24 hrs* UD UD UD 7.6D 2.7D 2.8U 5 5 4.7
NPR 2 weeks UD UD UD 2.5D 5.7D 3.1D 5 10 30
PI 24 hrs** 19.4 UD 56.6 0.7 3.7D 0.9 5 4.5 4.8
PI 2 weeks 2.7 UD 6.2 3.2D 0.9 2.9D 4.5 20 10
PNI day 8*** 22.2 UD UD 2.6D 2.2D 3.2D 4.8 4.5 4.2
PNI day 18 4.7 UD UD 4.3D 4.2D 3D 5 4.5 4.8
  1. *indicates non-pregnant immunized mice, **indicates pregnant immunized mice, ***indicates pregnant unimmunized mice. UD = undetectable, D = downregulation, U = upregulation.