Skip to main content

Table 1 Estimation of serum Th1/Th2 cytokine levels

From: Enhanced humoral response in pregnant mice immunized with liposome encapsulated recombinant neutralizing epitope protein of Hepatitis- E virus

Groups Time point Cytokine levels pg/ml (Std.error)
   IL-2 IFN-γ IL-12p40 IL-12 p70 IL-6 IL-10
Naiive   0.2(0) 0.2(0) 0.2(0) 0.2(0) 0.2(0) 12.0 (2.3)
NPR* 24 hrs 0.2(0) 0.2(0) 0.2(0) 0.2(0) 20.9 (1.92) 4.1 (1.1)
NPR 2 wks 0.2(0) 0.2(0) 0.2(0) 0.2(0) 8.3 (0.2) 10.2 ( 0.1)
PI** 24 hrs 19.4 (1.1) 56.6 (5.8) 0.2(0) 103 (7.2) 45.9 (1.4) 11.3 (1.5)
PI 2wks 2.7 (0.2) 6.2 (1.1) 28.9 (2.2) 36.4 (1.4) 25.5 (0.5) 23 (2.5)
PNI*** Day8 22.2 (0.2) 0.2(0) 0.2(0) 30.2 (2.4) 12.9 (0.7) 15.4 (0.4)
PNI Day18 4.7 (0.2) 0.2(0) 19.6 (0.4) 40.8 (3.1) 0.2(0) 25.6 (2.5)
p-values
naiive vs NPR 24 hrs N.S N.S N.S N.S <0.001 N.S
naiive vs NPR 2wks N.S N.S N.S N.S <0.001 N.S
NPR 24 hrs vs NPR 2wks N.S N.S N.S N.S <0.05 <0.05
PI 24 hrs vs PI 2wks <0.001 <0.001 <0.001 <0.05 N.S <0.05
PNI day8 vs PNI day18 <0.001 N.S <0.05 N.S <0.05 <0.05
PI 24 hrs vs PNI day8 N.S <0.001 N.S <0.001 <0.05 N.S
PI 2wks vs PNI day18 N.S <0.05 N.S N.S <0.001 N.S
NPR 24 hrs vs PI 24 hrs <0.001 N.S <0.001 <0.001 <0.05 <0.001
NPR 2wks vs PI 2wks <0.001 <0.001 <0.001 <0.001 <0.001 <0.05
  1. *indicates non-pregnant immunized group, **PI = pregnant immunized group, ***PNI = pregnant non-immunized mice group.
  2. N.S. = not significant, p > 0.05. (ANOVA test).