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Table 5 NAI inhibition of A/Fukui/45/2004 wild type and E119V enzyme activity and agglutination of RBCs

From: The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding

 

Wild type

E119V

  

NAI-HI nM b

 

NAI-HI nM b

 

IC 50 nM a

CRBC

TRBC

IC 50 nM a

CRBC

TRBC

Oseltamivir

1.7

1

1

260

10-100

10-100

Zanamivir

3.8

10

10

3.4

10

10

Peramivir

1.3

10

10

2.1

10

10

4-Amino DANA

970

1-10

1-10

25,100

1000

1000-10,000

  1. aIC50s for oseltamivir, zanamivir and peramivir from Barrett et al. [44].
  2. IC50 for 4-amino DANA mean of duplicate assays.
  3. bNAI-HI assays were performed in duplicate with 4 HAUs of virus and a final concentration 0.5% RBCs.
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Virology Journal

ISSN: 1743-422X