Figure 2

Heat map and unsupervised hierarchical cluster analysis of the differentially expressed miRNAs in EV71-infected cells and control cells. Total RNA from EV71-infected RD cells and uninfected RD cells in triplicate was used for microarray. Differentially expressed miRNAs were chosen with a log2 Ratio ≥ 0.5 and ≤ −0.5 and an adjusted P value < 0.05. Then columns and rows represent samples and particular miRNAs. The samples were correctly grouped together into EV71-infected cells and control cells according to the expression pattern The miRNA clustering tree is shown on the left. The color scale illustrates the relative expression level of miRNAs. Red color represents that the miRNA has higher expression in EV71-infected cells than in control, while green color represents that the miRNA has lower expression in EV71-infected cells than in control. The codes on the legend are log2-transformed values.