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Figure 4 | Virology Journal

Figure 4

From: Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody

Figure 4

Tfh cell proportions and circulating level of anti-ANT autoantibodies decreased after IL-21 inhibition. A. The percentages of Tfh cells in each groups investigated by flow cytometry. Tfh subsets were gated with CXCR5+ICOS+/CD4+ cells. Numbers in upper right quadrants represents an average number of positive cells in each group. All staining samples were restimulated with PMA/ionomycin for 4 h before analysis. B. The results of the Tfh cells statistical analysis. The percentages of Tfh cells in IL-21mAb group was fewer than control and PBS group. ▲ P < 0.05, versus normal group. ★ P < 0.05, versus isotype control mice. ◆ P < 0.05, versus PBS group mice. C. Anti-ANT autoantibody levels in the different groups. ▲ P < 0.05, versus normal group. ★ P < 0.05, versus isotype control mice. ◆ P <0.05, versus PBS group mice.

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Virology Journal

ISSN: 1743-422X