Integrin binding domain with the G-H loop and RGD sequence of VP1 [
]. Panel A shows the FMDV VP1 GH loop. Panel B shows the FMDV VP1 GH loop (as in panel A) in the context of αvβ3. The loop is predicted to bind in the crevice between the αv β-propeller domain (yellow/green ribbon) and the ligand-binding domain of β3 (purple/pink ribbon). Panel C shows a close up of panel B with the side chains of Leu (RGD + 1 and RGD + 4) shown as orange sticks projecting from the same face of the 310 helix.