Neutralization of IL-22 decreased the percentage of the Th22 cells, IL-22 and IL-22R. A. Th22 cells in anti-IL-22 Ab, IgG and PBS treated mouse groups were investigated by flow cytometry at week 2 and 12. B. The levels of circulating IL-22 measured by ELISA. C. Morphometric quantitation of cardiac IL-22R protein expression detected by IHC. D. Representative IL-22R immunohistochemistry images in heart tissue in anti-IL-22 Ab, IgG control and PBS treated mouse groups (Dark brown granules, original magnification × 400).