Table 1 Demographics and clinical characteristics of the 6 analyzed clusters

province (site code)

Kandal (KD02)

Kampong Speu (KS02)

Kandal (KD02)

Ratanakiri (RK01)

SteungTreng (ST02)

Kratie (KT02)

enrollment period, (day duration)

24-31 Aug (8 d)

12-16 Oct (7 d)

05-18 Mar (14 d)

25 Jul-12 Sep (50 d)

13-16 Feb (4 d)

4 Apr (1 d)

season

Rainy

Rainy

Dry

Rainy

Dry

Dry

number of cases

20

22

11

11

11

10

median age [range]

36.5 [4–71]

11 [2–60]

26 [6–45]

4 [2–5]

19 [18–49]

23 [2–43]

female/male, n (%)

9 (45)/11 (55)

12 (55)/10 (45)

8 (73)/3 (27)

4 (36)/7 (64)

4 (36)/7 (64)

8 (80)/2 (20)

fever present, median (duration day)

4 [2–4]

4 [2–6]

3 [2–4]

4 [2–6]

3 [2–3]

3 [2–5]

virus type detected (n)

EV-D68 (6); HRV-C (4); HRV-A; RSV-B

RSV-B (5); EV-D68; HRV-A; HRV-B; HRV-C

ADV; HRV-B

RSV-A (9); CV-B4; EV-D68; HCoV-OC43; HRV-C

HRV-B (3); HCoV-OC43

HRV-A (3); HRV-C; HCoV-229E

Symptoms

headache, n (%)

18 (90)

21 (95.5)

11 (100)

7 (63.5), 4 NA^‡

11 (100)

10 (100)

cough, n (%)

18 (90)

22 (100)

11 (100)

11 (100)

8 (73)

5 (50)

malaise, n (%)

15 (75)

21 (95.5)

4 (36.5)

11 (100)

0

0

chills, n (%)

0

21 (95.5)

5 (45.5)

3 (27.5)

7 (63.5)

2 (20)

muscle ache n (%)

3 (15)

0

1 (9)

0, 4 NA

0

7 (70)

joint pain, n (%)

8 (40)

0

1 (9)

0, 6 NA

2 (18)

1 (10)

seizure, n (%)

0

0

0

1 (9)

0

0

sore throat, n (%)

12 (60)

4 (18)

11 (100)

3 (27.5), 8 NA

1 (9)

6 (60)

shortness of breath, n (%)

0

0

0

10 (91)

0

0

nausea, n (%)

0

0

0

9 (82)

0

0

vomiting, n (%)

1 (5)

0

10 (91)

8 (73)

0

0

abdominal cramps, n (%)

1 (5)

0

2 (18)

1 (9), 4 NA

0

0

Site Diagnosis*

pharyngitis, n (%)

11 (55)

3 (13.5)

10 (91)

0

0

0

influenza, n (%)

7 (35)

5 (23)

1 (9)

0

0

7 (70)

pneumonia, n (%)

1 (5)

0

0

11 (100)

0

0

bronchitis, n (%)

0

1 (4.5)

0

0

0

0

upper respiratory infection, n (%)

0

13 (59)

0

0

0

0

malaria, n (%)

0

0

0

0

11 (100)

3 (30)

other, n (%)

1 typhoid fever

0

0

0

0

0