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Table 1 Antiviral activity against EV71, cytotoxicity, and selectivity index (SI) of pimprinine, pimprinethine, WS-30581 A and WS-30581 B in RD cells

From: Antiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces sp

Tested compound

CC50 a(μM)

EC50 b(μM)

EC90 c(μM)

SI d

Pimprinine

1455 ± 27e

89 ± 18

149 ± 12

16

Pimprinethine

835 ± 20

35 ± 4

42 ± 3

24

WS-30581 A

363 ± 13

16 ± 1

26 ± 6

23

WS-30581 B

229 ± 10

11 ± 3

18 ± 2

21

Ribavirinef

1230 ± 355

102 ± 68

136 ± 49

12

  1. aCC50, compound concentration required to reduce cell viability by 50%.
  2. bEC50, compound concentration required to achieve 50% protection from virus-induced cytopathogenicity.
  3. cEC90, compound concentration required to achieve 90% virus yield reduction.
  4. dSI (selectivity index), ratio CC50/EC50.
  5. eValues represent the mean ± SD of three independent experiments.
  6. fRibavirin, used as a positive control.
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Virology Journal

ISSN: 1743-422X