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Table 1 Proliferative and Elispot responses in chronically HCV-infected, exposed and uninfected volunteers

From: Hepatitis C virus-specific cellular immune responses in individuals with no evidence of infection

  

PROLIFERATION

ELISPOT

VOLUNTEERS

CORE

NS3

CEF

CORE

NS3

CEF

No risk

All

2/61 (3)4

4/62 (6)

24/62 (39)

8/65 (12)

0/59 (0)

31/58 (53)

UI 1

No risk

1/29 (3)

1/30 (3)

10/30 (33)

4/33 (12)

0/29 (0)

13/28 (46)

 

At risk

1/32 (3)

3/32 (9)

14/32 (44)

4/32 (13)

0/30 (0)

18/30 (60)

EUI 2

0/17 (0)

0/17 (0)

5/17 (29)

6/20 (30)

1/11 (9)

6/11 (55)

CI 3

3/17 (18)

2/16 (12,5)

9/16 (56)

8/20 (40)

2/6 (33)

3/6 (50)

  1. 1: Uninfected individuals (UI); 2: Exposed uninfected partners (EUI) of, 3: chronically HCV-infected (CI) individuals. 4: number positive/total number tested (percent). Control antigen (CEF) : There were no statistical difference in the frequencies of proliferative or elispot responses to CEF when comparing each group 2 by 2. HCV antigens : There were no statistical difference in the frequencies of proliferative response to both Core and NS3 when comparing each group 2 by 2; The frequencies of Elispot response to Core were higher in the CI group compared to UI no risk (p = 0.04) and to UI at risk (p = 0.04). The frequencies of Elispot response to NS3 were higher in the CI group compared to UI no risk (p < 0.03) and to UI at risk (p < 0.03).
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Virology Journal

ISSN: 1743-422X