Table 3 Sequence similarities and characterization of differentially expressed transcripts of HPAI H5N1 infected Chicken Brain

Gallus gallus vimentin (VIM), mRNA (down regulated)

NM_001048076

96%

Part of cytoskeleton system and vital in maintaining cell morphology, regulating the progress of protein synthesis, enabling cellular motion, and playing important roles in both intracellular transport and cell division.

Gallus gallus heat shock 70 kDa protein 2 (HSPA2), mRNA (up regulated)

NM_001006685

100%

Protein folding, stress response

Unknown sequence (down regulated)

Influenza A virus (A/goose/Hubei/65/2005(H5N1)) segment 3 polymerase PA (PA) gene, complete cds (up regulated)

HM172312

99%

Subunit of the trimeric complex of the RNA-dependent-RNA polymerase of Influenza A, involved in transcription of viral RNAs

PREDICTED: Gallus-gallus septin similar to PHD finger protien 2 (LOC415981), mRNA (up regulated)

XM_414324

96%

Involved in chromatin-mediated gene regulation

Gallus gallus septin 5 (Sep-05), mRNA (up regulated)

NM_001030654

96%

parkin substrate; vesicle and membrane associated protein that plays a significant role in inhibiting exocytosis.

Gallus gallus dihydropyrimidinase-like 2 (DPYSL2), mRNA (up regulated)

NM_204494

99%

Neural signal transduction associated protein

PREDICTED: Gallus gallus hypothetical protein LOC769149 (LOC769149), mRNA (down regulated)

XM_001232361

100%

Gallus gallus synaptosomal-associated protein, 25 kDa (SNAP25), mRNA (up regulated)

NM_205458

100%

Clonorchis sinensis clone ACP-2U-114 (down regulated)

EU780129

100%

Gallus gallus finished cDNA, clone ChEST766i3 (down regulated)

CR406701

96%

Gallus gallus tubulin folding cofactor D (TBCD), mRNA (down regulated)

NM_001012801

90%

Involved in the pathway leading to correctly folded beta-tubulin from folding intermediates