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Table 1 Rapid modulation in the frequency of lymphoid and myeloid immune cells in PRRSV-infected pigs.

From: Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions

Immune cells CD3+ (T)cells aCD4+T cells aCD8+T cells aCD4+CD8+ Th/memory
Day-0 51.1 ± 11.1f 21.4 ± 6.3 12.5 ± 3.5 23.0 ± 5.3
Day-2 contact 51.7 ± 15.8 18.9 ± 8.9 20.8 ± 10.3* 21.0 ± 6.8
Day-2 infected 60.7 ± 15.2 17.9 ± 5.9 7.8 ± 2.3#, $ 11.0 ± 3.5#, $
Immune cells b NK cells c γδ T cells d Myeloid cells e Tregs
Day-0 20.0 ± 11.2 25.6 ± 9.7 27.4 ± 6.1 0.2 ± 0.1
Day-2 contact 38.0 ± 23.9* 15.6 ± 7.9* 18.5 ± 12.8* 1.0 ± 0.6*
Day-2 infected 31.1 ± 18.7 27.2 ± 7.2$ 11.3 ± 8.9#, $ 1.1 ± 0.4#
  1. aCD3+ and bCD3-cells were gated to enumerate CD4 and CD8α expression and grouped as follows: total T lymphocytes (CD3+ T cells); CD4+ T cells (CD3+CD4+CD8α-); CD8+ T cells (CD3+CD4-CD8α+); Th/memory cells (CD3+CD4+CD8α+); NK cells rich fraction (CD3-CD4-CD8α+). Other immune cells: c γδ T cells (CD8α+TcR1N4+); dMyeloid cells (CD172+). eCD25+ cells were gated to enumerate CD4 and Foxp3 expressing cells and the percent of total CD4+CD25+Foxp3+ cells are shown. PBMCs of all the seven contact viremic pigs were used in the study. fEach number is an average percent of immune cells from 7 to 13 pigs +/-standard deviation. Symbols indicate statistically significant difference (P < 0.05) between: *-day 0 and day 2 contact; #-day 0 and day 2 infected; $-day 2 contact and day 2 infected pig groups, analyzed by Wilcoxon t-test.
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