Immunogen | Number surviving/total | Survival ratio (%) | P (versus PBS) |
|---|
PBS | 0/11 | 0 | / |
10 μg of rNP | 4/11 | 36.4 | 0.09 |
30 μg of rNP | 8/11 | 72.7 | 0.01 |
90 μg of rNP | 7/9 | 77.8 | 0.005 |
RVJ1175NP | 10/11 | 91.0 | 0.0001 |
- Note: The immunized mice were challenged with 10×MLD50 of influenza virus A/PR/8/34(H1N1) ten days after the last immunization. N = 11 per group, except n = 9 for the 90 μg rNP group because two mice were killed while being anesthetized. No significant differences were observed between each rNP group, or between the rNP- and RVJ1175NP-immunized groups. The P-values shown here were calculated compared to the PBS control group.
