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Table 2 Mouse survival calculation after influenza virus A/PR/8/34(H1N1) challenge

From: Influenza A virus nucleoprotein derived from Escherichia coli or recombinant vaccinia (Tiantan) virus elicits robust cross-protection in mice

Immunogen Number surviving/total Survival ratio (%) P (versus PBS)
PBS 0/11 0 /
10 μg of rNP 4/11 36.4 0.09
30 μg of rNP 8/11 72.7 0.01
90 μg of rNP 7/9 77.8 0.005
RVJ1175NP 10/11 91.0 0.0001
  1. Note: The immunized mice were challenged with 10×MLD50 of influenza virus A/PR/8/34(H1N1) ten days after the last immunization. N = 11 per group, except n = 9 for the 90 μg rNP group because two mice were killed while being anesthetized. No significant differences were observed between each rNP group, or between the rNP- and RVJ1175NP-immunized groups. The P-values shown here were calculated compared to the PBS control group.