Kinetics of CDV-neutralizing antibody titers in dogs inoculated pCMV3ISS-CDVH or Tetradog®. Groups of 4 dogs were administered either 100 μg of pCMV3ISS-CDVH, intradermally, or 1 ml of Tetradog®, intramuscularly and compared to a group of 3 sham-vaccinated animals (100 μg of pCMV3ISS). All the dogs were blood-sampled at days 0, 30, 60, 90 and 365 post-vaccination. Titers were expressed as the highest dilution of sera that inhibited the cytopathic effect of CDV-Onderstepoort strain. Results correspond to the mean antibody titers (the highest dilution of sera that inhibited the cytopathic effect of CDV-Onderstepoort strain) of the corresponding dogs in each group.