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Table 4 Various antigenically important amino acid/motifs/deletions observed in different gene segments of Pakistani H5N1 viruses

From: Sequence and phylogenetic analysis of highly pathogenic avian influenza H5N1 viruses isolated during 2006–2008 outbreaks in Pakistan reveals genetic diversity

 

HPAI AA Motif

HA 222

HA 224

NA Deletion

49-68

NA 275

MP 26

MP 27

MP 30

MP 31

MP 34

NS Deletion 80-84

NS 149

PDZ Binding domain

PB2 627

Ck/Rawalakot/2441/06

PQGERRRKKRGLF

Q

G

YES

H

L

V

A

S

G

YES

A

ESKV

K

Ck/Sihala/3303/06

PQGERRRKKRGLF

Q

G

YES

H

L

V

A

S

G

YES

A

ESKV

K

Ck/Laore/3320/06

PQGERRRKKRGLF

Q

G

YES

H

L

V

A

S

G

YES

A

ESKV

K

Gs/Lahore/3321/06

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Pck/Mansehra/7558/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Gs/Islamabd/7757/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Tk/Islamabad/7871/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Tk/Islamabad/7873/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Crow/Peshawar/7914/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Pck/Chakshahzad/9238/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Ck/Mansehra/10337/07

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

-

-

-

-

Ck/Karachi/520/08

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

YES

A

ESKV

-

Ck/Lahore/610/08

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

YES

A

ESKV

-

Ck/Karachi/612/08

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

YES

A

ESKV

-

Crow/Karachi/11672/08

PQGERRRKKRGLF

Q

G

YES

H

-

-

-

-

-

YES

A

ESKV

-

  1. Ck: Chicken, Gs: Goose, Ty: Turkey, Cw: Crow, Pk: Peacock, Pak: Pakistan.
  2. Not done/Data not available.
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Virology Journal

ISSN: 1743-422X