Table 1 Specific amino acid substitutions/insertions/deletions in the ORF1-3 regions of HEV genotype 4 strains
Region | Amino acid variation and site |
|---|---|
ORF1 | Substitutions: Q486E, R491L, E494D, A501E, F502P/L/E, E503A/V, S505L/V/I/F, D508S, P509G, A510T/S, T/A524H/Y/T, D1574N |
HVR | Substitutions: T707V, D713C |
ORF2 | Substitutions: I66V, P/S67V/F/L, T/A68S/P, A/T69Q, T/A70S/P, P/S97A/T/V, A114S, T/A146S, I147V, T149S/A, S161N, S324T, S/G326T, K330R, G509A, C580A, N587S, S590A |
ORF3 | 2 aa insertions (5P, 84Q) , 1 aa substitution (A35V) and 1 aa deletion (aa residue 68) |