Neutralization of IL-22 decreased the percentage of the Th22 cell, dysregulated the expressions of IL-22–IL-22R pathway on day 14 post infection. A. The result of statistical analysis for the alterations of Th22 cells in Anti-IL-22 Ab,IgG control and PBS groups, investigated by flow cytometry. B. The levels of plasma IL-22 were measured by ELISA. C. Morphometric quantitation of cardiac IL-22 protein expressions were explored by IHC. D. Relative cardiac expressions of IL-22/IL-22 receptor complex gene were detected by RT-PCR. *p < 0.05, **p < 0.01. Data are mean ± SD.