Figure 2

Histopathological examinations. Time course of the biopsies is shown in Figure 4. (a) (b) Biopsy from erythema on the chest showed clustering atypical lymphocytes at the dermo-epithelial junction, also known as Pautrier’s microabscesses and a moderate infiltration of atypical cells in the upper dermis. (hematoxylin and eosin (H&E) stain, original magnification (a): ×100; (b): ×400). (c) Biopsy of the vesicles demonstrated erosion with the degenerated epidermis and concomitantly clustering atypical lymphocytes, Pautrier’s microabscesses (arrows) (H&E stain, original magnification × 40). (d) Magnified view of the square in (c) revealed acantholytic and swollen cells (arrows) with neutrophil (H&E stain, original magnification × 400). (e) HSV in epidermal cells at vesicles (Immunohistochemical staining with anti-HSV antibody, original magnification × 400).