Figure 1From: Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolatesPhylogenetic analysis of the NS5B partial genomic region (256 nt, 8302–8556) of HCV G1 strains. Genetic distance was estimated by Kimura 2 parameters and phylogenetic tree was constructed with the Neighbor joining method. Bootstrap values over 50% are shown in the tree. Isolates are designated by their GenBank accession number, followed by their country of origin, except for Venezuelan ones, which are numbered and preceded by a C. G1a sequences harboring D310N substitution were included, and a similar number of sequences not harboring these mutations, from Venezuela (n = 23), Brazil (BRA, n = 8) and USA (n = 6). The same criteria of selection was applied to G1b sequences, respect to C316N substitution, from Venezuela (n = 23), Brazil (n = 6) and Asia (n = 7 from HK: Hong Kong, JAP: Japan and CHI: China). Sequences grouped in clades containing D310N or C316N substitutions are shown in brackets. Percent identities over 98% are shown for these clades.Back to article page