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Table 1 Summary of morphological observations of VLPs under different storage conditions

From: Stability studies of HIV-1 Pr55gagvirus-like particles made in insect cells after storage in various formulation media

Storage time (months)

Formulation medium

Temperature

1

3

6

12

PBS

4°C

√

×

nd

nd

 

-20°C

±

×

nd

nd

 

-70°C

±

×

nd

nd

5% Trehalose

4°C

×

nd

nd

nd

 

-20°C

±

×

nd

nd

 

-70°C

×

nd

nd

nd

15% Trehalose

4°C

√

×

nd

nd

 

-20°C

√

√

√

√

 

-70°C

√

√

√

√

5% Sucrose

4°C

×

nd

nd

nd

 

-20°C

×

nd

nd

nd

 

-70°C

×

nd

nd

nd

15% Sucrose

4°C

√

×

nd

nd

 

-20°C

√

±

×

nd

 

-70

√

√

×

nd

5% Sorbitol

4°C

nd

nd

nd

nd

 

-20°C

±

×

nd

nd

 

-70°C

±

×

nd

nd

15% Sorbitol

4°C

4°C

nd

nd

nd

 

-20°C

√

×

nd

nd

 

70°C

√

±

×

nd

  1. √: the formulated VLP micrograph is identical to that of the fresh batch.
  2. ±: 50% or more of the formulated VLPs in the micrograph have changed shape.
  3. ×: 100% of the formulated VLPs have changed shape.
  4. nd: not determined.
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Virology Journal

ISSN: 1743-422X