Skip to main content
Figure 5 | Virology Journal

Figure 5

From: Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1) expression to mediate proliferation and migration of hepatoma cells

Figure 5

Activation of PI3-kinase pathway on LASP-1 expression by HBx. (A). HBx induces activation of PI3-kinase in HepG2-HBX and Huh-7-HBX cells. The protein levels of phosphorylated Akt and Akt in cellular extracts were detected by Western blot analysis. HepG2-Mock cells and Huh-7-Mock cells served as controls. (B). Activation of PI3-kinase on LASP-1 expression by HBx was inhibited by LY294002. HepG2-HBX and Huh-7-HBX cells were cultured in 0.01% DMSO in the absence or presence of 20 μM or 30uM LY294002 and incubated for 8 h, cell lysates were prepared and subsequently performed by Western blot analysis. *P < 0.05 compared with control cells. #P < 0.05 compared with the HBx stable expressing cells.

Back to article page

Virology Journal

ISSN: 1743-422X