Table 1 Predicted targets of modulated miRNAs upon RABV infection involved in immune response pathways
miRNA | KEGG pathway | Target genes | Number of targets | P value |
|---|---|---|---|---|
mmu-miR-377 | mmu04630: Jak-STAT signaling pathway | CSF2RB2, EP300, JAK2, SOCS4, BCL2L | 5 | 0.01 |
mmu-miR-377 | mmu04010: MAPK signaling pathway | CACNA2D1, FASL, PPM1A, PPP3R1, RASA1, FLNC, PLA2G4A, SRF | 8 | 0.02 |
mmu-miR-377 | mmu04060: Cytokine-cytokine receptor interaction | CSF2RB2, FASL, ACVR2A, VEGFA, IL18RAP, KITL, PDGFRA, LTB | 8 | 0.001 |
mmu-miR-377 | mmu04666: Fc gamma R-mediated phagocytosis | WASF1, LIMK1, PRKCD, PLA2G4A, RPS6KB1 | 5 | 0.01 |
mmu-miR-377 | mmu04520: Adherens junction | WASF1, EP300, YES1, PVRL4, PTPRB, SMAD4 | 6 | 1.18E-06 |
mmu-miR-377 | mmu04310: Wnt signaling pathway | EP300, WNT5A, PPP3R1, FZD3, FZD4, AXIN1, BTRC, SMAD4, CUL1, DKK1 | 10 | 3.62E-04 |
mmu-miR-377 | mmu04360: Axon guidance | PPP3R1, RASA1, LIMK1, SEMA6A, SEMA3D | 5 | 0.001 |
mmu-miR-377 | mmu04110: Cell cycle | EP300, ESPL1, CDC26, CUL1 | 4 | 0.007 |
mmu-miR-377 | mmu04350: TGF-beta signaling pathway | EP300, ACVR2A, THBS1, PITX2, SMAD4, CUL1, LEFTY2, RPS6KB1 | 8 | 6.96E-06 |
mmu-miR-377 | mmu04510: Focal adhesion | MYLK2, XIAP, ITGA6, VEGFA, THBS1, PDGFRA, FLNC, LAMC1 | 8 | 0.018 |
mmu-miR-691 | mmu04630: Jak-STAT signaling pathway | GHR, SPRY2, TYK2, SPRED2, IL12A, CLCF1 | 6 | 0.01 |
mmu-miR-691 | mmu04010: MAPK signaling pathway | PLA2G10, MKNK2, MAPKAPK3, CACNB2, TGFBR2, DUSP9 | 5 | 0.02 |
mmu-miR-691 | mmu04060: Cytokine-cytokine receptor interaction | GHR, ACVR2A, BMP2, IL25, AMHR2, IL12A, TGFBR2, TNFSF14, CLCF1 | 9 | 0.001 |
mmu-miR-691 | mmu04666:Fc gamma R-mediated phagocytosis | LYN, INPP5D | 2 | 0.01 |
mmu-miR-691 | mmu04520: Adherens junction | CSNK2B, SRC, CDH1, TGFBR2 | 4 | 1.18E-06 |
mmu-miR-691 | mmu04310: Wnt signaling pathway | DKK2, CSNK2B, CAMK2G, CTBP2, VANGL1 | 5 | 3.62E-04 |
mmu-miR-691 | mmu04360: Axon guidance | PTK2, SEMA6D, ABLIM1, NRP1, PLXNA2, SRGAP3, SEMA5A | 7 | 0.001 |
mmu-miR-691 | mmu04110: Cell cycle | YWHAB, TFDP1 | 2 | 0.007 |
mmu-miR-691 | mmu04350: TGF-beta signaling pathway | ACVR2A, BMP2, THBS1, AMHR2, TFDP1, SP1, TGFBR2 | 7 | 6.96E-06 |
mmu-miR-691 | mmu04510: Focal adhesion | PTK2, IBSP, ITGA10, PGF, CAPN2, THBS1, SRC | 7 | 0.018 |
mmu-miR-1935 | mmu04630: Jak-STAT signaling pathway | LIFR, SPRY3 | 2 | 0.01 |
mmu-miR-1935 | mmu04010: MAPK signaling pathway | MAP3K12, FLNC, MAPT | 3 | 0.02 |
mmu-miR-1935 | mmu04060: Cytokine-cytokine receptor interaction | ACVR1, HGF, LIFR, CCR10 | 4 | 0.001 |
mmu-miR-1935 | mmu04666: Fc gamma R-mediated phagocytosis | MARCKS | 1 | 0.01 |
mmu-miR-1935 | mmu04520: Adherens junction | YES1, PVRL1 | 2 | 1.18E-06 |
mmu-miR-1935 | mmu04310: Wnt signaling pathway | NFAT5 | 1 | 3.62E-04 |
mmu-miR-1935 | mmu04360: Axon guidance | NFAT5, PLXNA4, SRGAP2, DCC | 4 | 0.001 |
mmu-miR-1935 | mmu04110: Cell cycle | STAG1, CDKN1C | 2 | 0.007 |
mmu-miR-1935 | mmu04510: Focal adhesion | FLNC | 1 | 0.018 |
mmu-miR-190 | mmu04630: Jak-STAT signaling pathway | IL6 | 1 | 0.01 |
mmu-miR-190 | mmu04010: MAPK signaling pathway | FASL, PLA2G6, BDNF, FGF14 | 4 | 0.02 |
mmu-miR-190 | mmu04060: Cytokine-cytokine receptor interaction | FASL, HGF, IL6, CXCL16 | 4 | 0.001 |
mmu-miR-190 | mmu04666: Fc gamma R-mediated phagocytosis | PLA2G6, ARPC5 | 2 | 0.01 |
mmu-miR-190 | mmu04520: Adherens junction | SMAD2, TJP1 | 2 | 1.18E-06 |
mmu-miR-190 | mmu04310: Wnt signaling pathway | SMAD2, PPP2R1B, ROCK1, PLCB1 | 4 | 3.62E-04 |
mmu-miR-190 | mmu04360: Axon guidance | EPHA1, ROCK1 | 2 | 0.001 |
mmu-miR-190 | mmu04110: Cell cycle | SMAD2, CHEK1, RBL1 | 3 | 0.007 |
mmu-miR-190 | mmu04350: TGF-beta signaling pathway | SMAD2, PPP2R1B, PITX2, ROCK1, RBL1 | 5 | 6.96E-06 |
mmu-miR-190 | mmu04510: Focal adhesion | CAPN2, HGF, ROCK1 | 3 | 0.018 |
mmu-miR-135a* | mmu04630: Jak-STAT signaling pathway | EP300,IL24,IFNAR2,IL12RB1,IFNG | 5 | 0.01 |
mmu-miR-135a* | mmu04060: Cytokine-cytokine receptor interaction | IL24,IFNAR2,IL12RB1,IFNG,CXCL16,CD40LG | 6 | 0.001 |
mmu-miR-135a* | mmu04666: Fc gamma R-mediated phagocytosis | NCF1 | 1 | 0.01 |
mmu-miR-135a* | mmu04520: Adherens junction | EP300, ACTN2 | 2 | 1.18E-06 |
mmu-miR-135a* | mmu04310: Wnt signaling pathway | EP300, WNT1, PPP2R1A | 3 | 3.62E-04 |
mmu-miR-135a* | mmu04110: Cell cycle | EP300, YWHAQ, ANAPC7 | 3 | 0.007 |
mmu-miR-135a* | mmu04350: TGF-beta signaling pathway | EP300, BMP4, IFNG, PPP2R1A | 4 | 6.96E-06 |
mmu-miR-135a* | mmu04510: Focal adhesion | PTEN, ITGA8, ACTN2 | 3 | 0.018 |
mmu-miR-290-5p | mmu04630: Jak-STAT signaling pathway | IL13RA1, IFNGR2, AKT1, CSF2RB | 4 | 0.01 |
mmu-miR-290-5p | mmu04010: MAPK signaling pathway | GADD45A, MAPKAPK3, MEF2C, MAP3K1, AKT1FGF23 | 5 | 0.02 |
mmu-miR-290-5p | mmu04060: Cytokine-cytokine receptor interaction | IL13RA1, IL18R1, CD40, IFNGR2, CXCL12, ACVR1B, CSF2RB | 7 | 0.001 |
mmu-miR-290-5p | mmu04666: Fc gamma R-mediated phagocytosis | MARCKS, AKT1 | 2 | 0.01 |
mmu-miR-290-5p | mmu04520: Adherens junction | LMO7, ERBB2, PTPRB, LEF1, INSR, SSX2IP, PVRL3 | 7 | 1.18E-06 |
mmu-miR-290-5p | mmu04310: Wnt signaling pathway | LEF1, CAMK2G, PLCB1, AXIN2 | 4 | 3.62E-04 |
mmu-miR-290-5p | mmu04360: Axon guidance | ROBO1, L1CAM, SEMA5B, CXCL12 | 4 | 0.001 |
mmu-miR-290-5p | mmu04110: Cell cycle | SMC3, MCM5, GADD45A, CDC25A, TFDP1, HDAC2, RAD21, ORC5L | 8 | 0.007 |
mmu-miR-290-5p | mmu04350: TGF-beta signaling pathway | TFDP1 | 1 | 6.96E-06 |
mmu-miR-290-5p | mmu04510: Focal adhesion | XIAP, ERBB2, AKT1 | 3 | 0.018 |
mmu-miR-203 | mmu04630: Jak-STAT signaling pathway | IL24, CNTFR, IL22RA2, CCND1, SOCS3, AKT2, IL12B | 7 | 0.01 |
mmu-miR-203 | mmu04010: MAPK signaling pathway | CACNA2D1, MAP3K13, DUSP5, MAP4K3, STK3, NLK, AKT2, ATF2, PDGFRA, RAP1A, MAPT, MAP3K1, PPM1B, FGF7, CRK, PRKCA | 16 | 0.02 |
mmu-miR-203 | mmu04060: Cytokine-cytokine receptor interaction | MET, IL24, CNTFR, ACVR2A, IL22RA2, VEGFA, XCL1, PDGFRA, IL12B | 9 | 0.001 |
mmu-miR-203 | mmu04666: Fc gamma R-mediated phagocytosis | PLD2, AKT2, DNM1L, PPAP2B, CRK, VAV3, PRKCA | 7 | 0.01 |
mmu-miR-203 | mmu04520: Adherens junction | MET, NLK, SRC, PTPRB, SNAI2 | 5 | 1.18E-06 |
mmu-miR-203 | mmu04310: Wnt signaling pathway | SFRP2, CCND1, NLK, APC, CSNK1A1, CUL1, PRKCA | 7 | 3.62E-04 |
mmu-miR-203 | mmu04360: Axon guidance | MET, ABL1, SEMA3A, SEMA6A, SEMA5A | 5 | 0.001 |
mmu-miR-203 | mmu04110: Cell cycle | YWHAQ, CCND1, ABL1, SKP2, CUL1 | 5 | 0.007 |
mmu-miR-203 | mmu04350: TGF-beta signaling pathway | ACVR2A, ID2, BMP5, CUL1, ID4 | 5 | 6.96E-06 |
mmu-miR-203 | mmu04510: Focal adhesion | MET, PXN, CCND1, VEGFA, PPP1C, SRC, PDGFRA, RAP1A, RAPGEF1, TNC, COL4A4, CAV1, CRK, VAV3, PRKCA | 15 | 0.018 |
mmu-miR-145 | mmu04630: Jak-STAT signaling pathway | MYC, STAM, STAT4, SOCS7 | 4 | 0.01 |
mmu-miR-145 | mmu04010: MAPK signaling pathway | MAP3K3, HSPA1L, PPP3CA, DUSP4, MYC, RASA2, RAPGEF2, FLNB, DUSP6, TGFBR2, MAP4K4, CRKL | 12 | 0.02 |
mmu-miR-145 | mmu04060: Cytokine-cytokine receptor interaction | FLT3L, TNFRSF11B, IL17RB, INHBB, ACVR1B, TGFBR2 | 6 | 0.001 |
mmu-miR-145 | mmu04666:Fc gamma R-mediated phagocytosis | ARF6, CFL2, LAT, ARPC5, CRKL | 5 | 0.01 |
mmu-miR-145 | mmu04520: Adherens junction | YES1, ERBB2, CTNND1, ACTG1, SMAD3, ACTB, TGFBR2 | 7 | 1.18E-06 |
mmu-miR-145 | mmu04310: Wnt signaling pathway | PPP3CA, FZD9, MYC, CTNNBIP1, SMAD3, SENP2, WNT5B | 7 | 3.62E-04 |
mmu-miR-145 | mmu04360: Axon guidance | PPP3CA, CFL2, SRGAP1, DPYSL2, SEMA3, EFNB3, SRGAP2, ABLIM2, SEMA6A, PLXNA2, SEMA3D | 11 | 0.001 |
mmu-miR-145 | mmu04110: Cell cycle | MCM5, MYC, SMAD3, CDK6, SFN, ORC2L | 6 | 0.007 |
mmu-miR-145 | mmu04350: TGF-beta signaling pathway | MYC, SMAD3, INHBB, TGFBR2, SMAD5 | 5 | 6.96E-06 |
mmu-miR-145 | mmu04510: Focal adhesion | ERBB2, ACTG1, FLNB, ACTB | 4 | 0.018 |