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Table 1 A list of selected genes affected in the 293T cells by the transfection of A. expression vector [pcDNA3.0(-)] B. H5N1-NS1 clone and C. H11N1-NS1 clone

From: Non structural protein of avian influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing apoptosis in host cells

A. Vector

Gene ID

Gene Description

Fold change

NM_000981

ribosomal protein L19; ribosomal protein L19 pseudogene 12

3.2

NM_002295

ribosomal protein SA pseudogene 9

2.6

NM_000994

small nucleolar RNA, H/ACA box 7A; small nucleolar RNA, H/ACA box 7B; ribosomal protein L32

3.1

NM_001728

basigin (Ok blood group)

2.7

NM_002086

growth factor receptor-bound protein 2

2.9

NM_001237

cyclin A2

-4.6

NM_000389

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

-2.1

NM_002592

proliferating cell nuclear antigen

-2.6

NM_021138

TNF receptor-associated factor 2

-2.0

B. H5N1-NS1

Gene ID

Gene Description

Fold change

NM_007294

breast cancer 1, early onset

-2.0

NM_000618

insulin-like growth factor 1 (somatomedin C)

-2.8

NM_000876

insulin-like growth factor 2 receptor

-2.1

NM_003327

tumor necrosis factor receptor superfamily, member 4

-2.1

NM_001904

catenin (cadherin-associated protein), beta 1, 88 kDa

-2.0

NM_003505

frizzled homolog 1 (Drosophila)

-2.2

NM_001527

histone deacetylase 2

-2.3

NM_004642

cyclin-dependent kinase 2 associated protein 1

-2.0

NM_004060

cyclin G1

2.0

NM_000075

cyclin-dependent kinase 4

1.5

NM_001067

topoisomerase (DNA) II alpha 170 kDa

2.2

NM_001924

growth arrest and DNA-damage-inducible, alpha

2.5

NM_002755

mitogen-activated protein kinase kinase 1

1.5

NM_002467

v-myc myelocytomatosis viral oncogene homolog (avian)

1.5

NM_001414

eukaryotic translation initiation factor 2B, subunit 1 alpha, 26 kDa

2.0

NM_004953

eukaryotic translation initiation factor 4 gamma, 1

2.0

NM_002156

heat shock 90 kDa protein 1 (chaperonin)

-2.3

NM_007315

signal transducer and activator of transcription 1, 91 kDa

-1.5

NM_002228

jun oncogene

-2.1

C. H11N1-NS1

Gene ID

Gene Description

Fold change

NM_021138

TNF receptor-associated factor 2

-1.5

NM_001904

catenin (cadherin-associated protein), beta 1, 88 kDa

-1.5

NM_002228

jun oncogene

-1.5

NM_002750

mitogen-activated protein kinase 8

-2.0

NM_001924

growth arrest and DNA-damage-inducible, alpha

1.5

NM_002222

inositol 1,4,5-triphosphate receptor, type 1

2.0

NM_007315

signal transducer and activator of transcription 1, 91 kDa

1.5

NM_018955

ubiquitin B

3.2

NM_000459

TEK tyrosine kinase, endothelial

-2.1

NM_004428

ephrin-A1

-3.1

NM_006888

calmodulin 3 (phosphorylase kinase, delta)

2.3

X15183

heat shock protein 90 kDa alpha

-1.5