Table 2 Clinical characteristics at onset of severe acute exacerbation

Weeks of pegasys trreatment

2

8

2

HBeAg

+

_

_

Anti-HBe

_

+

+

HBV DNA (LC/ml)

5.74

6.23

4.10

WBC(10⁹/L)

3.82

2.95

4.24

Hb (g/L)

151

136

142

Plt(^x10⁹/L)

85

55

64

ALT (lU/L)

1672

419

566

AST (lU/L)

1533

320

394

AST/ALT ratio

0.92

0.76

0.70

ALP (lU/L)

175

177

188

y-GTP(lU/L)

170

181

318

Total protein(g/L)

57.7

70.6

60.0

Albumin (g/L)

34.2

33.0

34.5

Total bilirubin(μmol/L)

289.3

179.6

180.6

Direct bilirubin (μmol/L)

182.5

146.6

96.8

Prothrombin activity (%)

35

83.3

88.1

AFP (ng/ml)

89

774.1

56.2

Creatine (μmol/L)

44.3

57

72.7

FT3 (pmol/L)

3.6

3.2

3.8

FT4 (pmol/L)

12.4

13.4

11.9

TSH (mlU/L)

1.3

0.9

1.2