Protective immunity to Japanese encephalitis virus associated with anti-NS1 antibodies in a mouse model

Table 3 Survival rate of three month-old C3H mice immunized with NS1 or PBS

Immunogen	Anti-NS1 IgG antibody titer range^a	No. of Survival mice/No. of Immunized mice (Survival rate)	P ^b
NS1	0-12800	12/18 (66.7%)	0.41
NS1	0-2400	3/9 (33.3%)	1
NS1	2400-12800	9/9 (100%)	0.008
PBS	0	4/9 (44.4%)

^a Two weeks before challenge, mouse sera were collected for anti-NS1 IgG antibody titration. The NS1-immunized group of mice (18 mice in total) was divided into two groups according to anti-NS1 IgG titers: one group with anti-NS1 IgG <2400 (9 mice) and one group with anti-NS1 IgG >2400 (9 mice).
^bP value was obtained by log rank test when comparing the survival curve of each group with PBS group.

ISSN: 1743-422X