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Table 1 Interaction of HCV proteins with PRRs

From: Interaction of Hepatitis C virus proteins with pattern recognition receptors

HCV Proteins PRRs Interaction of HCV proteins with PRRs Escape from innate immune system Escape from adaptive immune system
Core TLR2 Induction of TLR2 homotolerance Serum derived or recombinant core does not recognize TLR2
   Induction of TLR2 crosstolerance with TLR4 Monomeric Core recognize core  
   TLR1 or TLR6 are used as coreceptors with TLR2 Net Effect = Delayed Immune Response  
NS3/4A TLR3 Block TRIF and Cadif (adapter proteins) in down-stream signaling pathways of TLR3 and RIG-1 respectively TLR3 and RIG-1 pathways are not activated until sufficient amount of dsRNA is produced, thus delaying innate immune response
  RIG-1    
  TLR2    
   TLR1 or TLR6 are used as coreceptors with TLR2   
NS5A TLR4 Increases TLR4 expressions Block MyD88 (adapter protein) of TLR4 signaling pathway
    Also downregulates the expression of NFkB, MD2, CD14 and IRF3  
    Increases secretion of IL6, IFNβ, TGFβ and IL10  
    Suppresses IL12 secretion