Table 2 The distribution and association of IL28B genotype with response to PEG-IFN-α/RBV treatment
SVR | NVR | Rel | NVR vs. SVR | P value | Rel vs. SVR | P value | |
|---|---|---|---|---|---|---|---|
N,% | N,% | N,% | OR(95%CI) | OR(95%CI) | |||
SNP genotype | |||||||
TT | 86(65.6%) | 10(21.3%) | 24(41.4%) | 1.0 (Reference) | 1.0 (Reference) | ||
TG | 40(30.5%) | 30(63.8%) | 28(48.3%) | 6.45(2.88–14.47) | <0.001 | 2.51(1.29–4.86) | 0.006 |
GG | 5(3.8%) | 7(14.9%) | 6(10.3%) | 12.04(3.21–45.13) | <0.001 | 4.30(1.21–15.13) | 0.017 |
TG+GG | 45(34.4%) | 37(78.3%) | 34(58.6%) | 7.07(3.22–15.52) | <0.001 | 2.71(1.44–5.11) | 0.002 |
Allele | |||||||
T allele | 212(80.9%) | 50(53.2%) | 76(65.5%) | 1.0 (Reference) | 1.0 (Reference) | ||
G allele | 50(19.1%) | 44(46.8%) | 40(34.5%) | 3.73(2.24–6.21) | <0.001 | 2.23(1.37–3.45) | 0.001 |