Prediction of response to pegylated-interferon-α and ribavirin therapy in Chinese patients infected with different hepatitis C virus genotype

Table 1 Demographic and biochemical features of patients

Variable	SVR	NVR	Rel	P value
Total no. of subjects	131	47	58
Age (years)	44.96 ± 10.85	40.87 ± 14.18	44.76 ± 10.97	0.106
Gender: male (%)	79(60.3%)	36(76.6%)	35(60.3%)	0.116
BMI	22.17 ± 2.94	22.01 ± 2.64	22.77 ± 3.43	0.352
ALT(U/L)	60(33–119)	57(38–89)	59(27–95)	0.315
AST(U/L)	49(34–120)	49(35–69)	45(28–73)	0.219
Platelet count (×10 ⁴ /mm ³ )	17.48 ± 5.42	17.16 ± 6.40	18.42 ± 11.35	0.641
HCV genotype 1 (%)	58(44.3%)	29(61.7%)	39(67.2%)	0.006
Fibrosis ^a : F3-F4 (%)	16(29.1%)	16(66.7%)	10 (45.5%)	0.007
Infection time ^b (year)	5(2–13)	5(3–12)	6(3–11)	0.952
Virus load (log IU/ml)	6.18 ± 1.17	6.08 ± 0.82	6.12 ± 1.05	0.617

a: 101 patients had ultrasound-guided percutaneous liver biopsies, all biopsy specimens were used for the histologic diagnosis b:duration of exposure on risk factors to initial anti-viral therapy.

ISSN: 1743-422X