A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease

Table 3 Cidofovir and vaccination combined treatment post ECTV challenge

Treatment^a	Day of treatment	Survival (%)	MTTD
CDV	3	100*	N.R.
CDV + VACV-Lister		90*	17
CDV + MVA		100*	N.R.
CDV	4	80*	14
CDV + VACV-Lister		50*	10.3
CDV + MVA		50*	11.6
CDV	5	30	11.3
CDV + VACV-Lister		40	12.8
CDV + MVA		40	13
Infected untreated	N.R.	0	10.3

^a Vaccinations 4 hours after CDV (5 mg/kg) were done using tail scarification with VACV-Lister (1X10⁶ pfu) or MVA i.m. (1X10⁸ pfu) at days 3, 4 or 5 after animals were challenged i.n. with 70–100 pfu = 70–100 LD₅₀ of ECTV. N = 10 in each group. N.R. – not relevant. * Refers to a statistically significant difference from the control infected untreated (Fisher's Exact test, P < 0.05).

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