Skip to main content

Table 2 Single CDV treatment in conjunction with VACV vaccination does not impair the development of protective immunity

From: A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease

Cidofovir (mg/kg)a

Vaccination post CDV (day)

"Clinical take" scoreb

IFN-gamma (pg/ml)c

IgG antibodies (GMT)d

5

0

3.0 ± 0

129 ± 12*

2540

1

3.0 ± 0

136 ± 48

3200

25

0

2.8 ± 0.2

151 ± 24*

5080

1

2.8 ± 0.2

185 ± 34*

2540

100

0

2.2 ± 0.4

105 ± 72

2540

1

3.0 ± 0

413 ± 131

4032

Controle

N.D.

3.0 ± 0

55 ± 20

4525

naïvesf

N.D.

N.R.

3 ± 2

<100

  1. a Mice were CDV treated at day 0 (4 hours) or day 1 (24 hours) prior to vaccination with VACV-Lister by tail scarification.
  2. b The "clinical take" score refers to the size and appearance of the tail lesion at the site of vaccination. The score was determined 13 days post vaccination (n = 6/group, mean ± SE).
  3. c IFN-gamma was examined in mice sera 7 days post vaccination (n = 3/group, mean ± SE).
  4. d Antibody titers in mice sera were determined at day 31 post vaccination (n = 3/group, GMT – geometric mean titer).
  5. e Control – vaccination without CDV treatment.
  6. fNaives – no treatment.
  7. * Indicates for statistical significance compared to the control vaccinated without CDV treatment (t-test, P < 0.05). N.D. – not done. N.R. – not relevant.
Back to article page

Virology Journal

ISSN: 1743-422X