Figure 1

Single dose of cidofovir post ECTV challenge confer protection in a time and dose dependent manner. Mice were challenged by intranasal instillation with a 15–100 pfu = 15–100 LD₅₀ of ECTV. A single dose of cidofovir was given at various days p.e. A: 2.5 mg/kg, B: 5 mg/kg, C: 10 mg/kg, D: 25 mg/kg, E: 50 mg/kg, F: 100 mg/kg. Weight loss was determined every 1–3 days. Means ± standard errors of percent of the initial body weights are presented. The control infected untreated group is a representative group (n = 6) from one of the experiments. Similar death profile was observed in all the other experiments. Numbers of animals in each group are indicated in Table 1.