Table 1 Genetic, demographic and Clinical background of 2009 pdm H1N1 influenza strains
From: Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice
A/Nanchang/8002/2009 (NC2) | A/Nanchang/8008/2009 (NC8) | A/Nanchang/8011/2009 (NC11) | ||
|---|---|---|---|---|
Day of sample collection | 9 Dec 2009 | 19 Dec 2009 | 22 Dec 2009 | |
Age (yrs) | 27 | 15 | 33 | |
Gender | M | F | F | |
Temperature (oC) | 39.4 | 38.5 | NA | |
Hospitalization | ✓ | ✓ | ✓ | |
Complications | NA | |||
Antiviral Treatment | ✓ | |||
Lethality in mice | Severe | Mild | Severe | |
Viral loads in mice lungs | High | Low | High | |
Replication in A549 cells | High | Moderate | High | |
£TCID50/ml | 1 x 104.83 | 1 x 104.33 | ND | |
EID50/ml | 1 x 106.4 | 1 x 107.75 | 1 x 106.4 | |
€PB2 | Genbank ID | JF800142 | CY089613 | CY089621 |
V227I | ✓ | |||
V295L | ✓ | |||
R299K | ✓ | |||
I310R | ✓ | |||
K353R | ✓ | |||
N556K | ✓ | |||
T588I | ✓ | |||
K660R | ✓ | |||
€PB1 | Genbank ID | JF800143 | CY089614 | CY089622 |
T257A | ✓ | |||
€PA | Genbank ID | CY089607 | CY089615 | CY089623 |
A70V | ✓ | ✓ | ||
P224S | ✓ | ✓ | ✓ | |
E243G | ✓ | |||
E319V | ✓ | |||
D547E | ✓ | |||