Figure 5From: Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in miceHeterogonous viral replication of pandemic influenza H1N1 strains in mice lungs. (a) Viral loads in the lungs of NC2, NC8 and NC11 infected C57/BL6 mice were determined at 1 d.p.i.. (b) Viral loads NC2 were also examined in C57/BL6 and BALB/C mice (n =3). Replication kinetics of NC2 and NC8 were compared in BALB/C mice infected with dose series of viruses at (c) 1 d.p.i. and (d) 3 d.p.i.. MDCK cells were used to determine viral loads in serially diluted lung homogenates collected at different time intervals. Results are presented as mean ± SEM of TCID50. Statistical differences were calculated by Mann Whitney U test. *** - P < 0.0001.Back to article page