Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

Table 1 Antiviral effect of intranasal prestimulation by lipopolysaccharide against influenza A/Puerto Rico/8/34.

LPS (mg/kg)^a	Pretreatment time	Ratio of MLD₅₀(log₁₀EID₅₀) between LPS-pretreated and mock-treated mice^b
0.15625	7 days	0
	3 days	1.0
	24 hrs	0
	12 hrs	0
0.3125	7 days	0.6
	3 days	1.26
	24 hrs	0
	12 hrs	0
0.625	7 days	1.0
	3 days	1.6
	24 hrs	1.0
	12 hrs	0.3
1.25	7 days	0
	3 days	1.94
	24 hrs	0.94
	12 hrs	0.94
	6 hrs	0.24
2.5	7 days	1.0
	3 days	1.3
	24 hrs	1.0
	12 hrs	0

^aEscherichia coli (serotype O26:B6)-derived lipopolysaccharide (LPS), MLD₅₀ = 36.4 (mg/kg)
^b "0" would be no difference and "1.0" would indicate that 10 times more virus is need to kill 50% of infected animals when treated with the indicated amount of LPS.

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