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Table 1 Antiviral effect of intranasal prestimulation by lipopolysaccharide against influenza A/Puerto Rico/8/34.

From: Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

LPS (mg/kg)a Pretreatment time Ratio of MLD50(log10EID50) between LPS-pretreated and mock-treated miceb
0.15625 7 days 0
  3 days 1.0
  24 hrs 0
  12 hrs 0
0.3125 7 days 0.6
  3 days 1.26
  24 hrs 0
  12 hrs 0
0.625 7 days 1.0
  3 days 1.6
  24 hrs 1.0
  12 hrs 0.3
1.25 7 days 0
  3 days 1.94
  24 hrs 0.94
  12 hrs 0.94
  6 hrs 0.24
2.5 7 days 1.0
  3 days 1.3
  24 hrs 1.0
  12 hrs 0
  1. aEscherichia coli (serotype O26:B6)-derived lipopolysaccharide (LPS), MLD50 = 36.4 (mg/kg)
  2. b "0" would be no difference and "1.0" would indicate that 10 times more virus is need to kill 50% of infected animals when treated with the indicated amount of LPS.