LPS (mg/kg)a
|
Pretreatment time
|
Ratio of MLD50(log10EID50) between LPS-pretreated and mock-treated miceb
|
---|
0.15625
|
7 days
|
0
|
|
3 days
|
1.0
|
|
24 hrs
|
0
|
|
12 hrs
|
0
|
0.3125
|
7 days
|
0.6
|
|
3 days
|
1.26
|
|
24 hrs
|
0
|
|
12 hrs
|
0
|
0.625
|
7 days
|
1.0
|
|
3 days
|
1.6
|
|
24 hrs
|
1.0
|
|
12 hrs
|
0.3
|
1.25
|
7 days
|
0
|
|
3 days
|
1.94
|
|
24 hrs
|
0.94
|
|
12 hrs
|
0.94
|
|
6 hrs
|
0.24
|
2.5
|
7 days
|
1.0
|
|
3 days
|
1.3
|
|
24 hrs
|
1.0
|
|
12 hrs
|
0
|
- aEscherichia coli (serotype O26:B6)-derived lipopolysaccharide (LPS), MLD50 = 36.4 (mg/kg)
- b "0" would be no difference and "1.0" would indicate that 10 times more virus is need to kill 50% of infected animals when treated with the indicated amount of LPS.