Transcriptomic profile of host response in Japanese encephalitis virus infection

Gupta, Nimesh; Rao, PV Lakshmana

doi:10.1186/1743-422X-8-92

Virology Journal

Table 3 Differential expression of cell surface molecules in brain after JEV infection.

From: Transcriptomic profile of host response in Japanese encephalitis virus infection

Biological Process	Gene Symbol	Accession No	Description	Fold change over mock-infected
				1 DPI	2 DPI	4 DPI	5 DPI
Immune response	Clec7a†	NM_020008	C-type lectin domain family 7	0.49	2.34	1.32	6.34
Immune response	Clec5a	NM_001038604	C-type lectin domain family 5	1.32	1.85	2.07	5.90
Protein binding scavenger	Lgals3bp	NM_011150	Lectin, galactoside-binding, soluble, 3 binding protein	4.23	3.58	3.92	4.90
Inflammatory response	Tlr2†	NM_011905	Toll-like receptor 2	0.87	1.34	1.40	4.90
Cell adhesion	Sell	NM_011346	Selectin, lymphocyte	-0.96	-0.55	-0.60	4.85
Inflammatory response	Siglec1†	NM_011426	Sialic acid binding Ig-like lectin 1	2.39	2.80	2.29	4.83
Immune response	Clec4e	NM_019948	C-type lectin domain family 4	-0.87	-0.46	-0.61	4.57
Signal transduction	Gpr84	NM_030720	G protein-coupled receptor 84	2.10	2.66	3.25	4.47
Endocytosis	Msr1	NM_031195	Macrophage scavenger receptor 1	-0.94	-0.56	1.10	4.40
Defense response	Tlr3†	NM_126166	Toll-like receptor 3	3.56	2.47	5.03	4.27
T cell mediated cytotoxicity	Ptprc	NM_011210	Protein tyrosine phosphatase, receptor	1.63	1.78	2.00	4.27
Signal transduction	Ccrl2†	NM_017466	Chemokine (C-C motif) receptor-like 2	1.66	2.50	1.98	4.16
Cytokine & Chemokine signaling	Lilrb3	NM_011095	Leukocyte immunoglobulin-like receptor	2.06	1.94	0.65	4.09
Immune response	Lgals3	NM_010705	Lectin, galactose binding, soluble 3	1.58	1.40	1.40	4.00
Defense response	Tlr1	NM_030682	Toll-like receptor 1	2.38	2.15	2.34	3.92
Apoptosis	Fas	NM_007987	Fas (TNF receptor superfamily)	0.24	0.79	0.77	3.90
Antibody-dependent cellular cytotoxicity	Fcgr1	BC025535	Fc receptor, IgG, high affinity I	4.23	1.72	3.05	3.79
Immune response	Masp2†	NM_010767	Mannan-binding lectin serine peptidase	1.66	2.74	3.70	3.75
ADP-ribosylation	Plec1	BC024074	Plectin 1	2.35	1.15	2.57	3.71
Inflammatory response	Tlr4	NM_021297	Toll-like receptor 4	2.11	1.96	2.15	3.57
Cytokine & Chemokine signaling	Csf2rb2	NM_007781	Colony stimulating factor 2 receptor	1.10	1.08	1.38	3.57
Inflammatory response	Selp	NM_011347	Selectin, platelet	-0.06	0.54	-0.67	3.57
Cell adhesion	Icam1†	BC008626	Intercellular adhesion molecule	0.85	0.85	0.82	3.57
NC	Lgals9	NM_010708	Lectin, galactose binding, soluble 9	2.27	1.18	2.41	3.54
Cytokine & Chemokine signaling	Csf2rb1	AK154286	Colony stimulating factor 2 receptor	0.57	1.23	1.43	3.52
Immune response	Il18bp	NM_010531	Interleukin 18 binding protein	2.59	0.90	1.72	3.32
NC	Fcgr4	NM_144559	Fc fragment of IgG, low affinity IIIa, receptor	2.06	1.17	3.39	3.31
Inflammatory response	Tlr7†	NM_133211	Toll-like receptor 7	0.52	0.97	1.80	3.26
Cell adhesion	Amica1	NM_001005421	Adhesion molecule, interacts with CXADR antigen 1	1.08	0.78	0.72	3.24
Immune response	Cd8a	NM_001081110	CD8 antigen, alpha chain	-0.97	-0.55	-0.60	3.15
Cell adhesion	Vcam1	NM_011693	Vascular cell adhesion molecule 1	1.06	0.54	0.83	3.13
Phagocytosis	Fcgr2b	NM_010187	Fc receptor, IgG, low affinity IIb	0.19	0.65	0.17	3.09
Signal transduction	Osmr	NM_011019	Oncostatin M receptor	0.52	0.36	1.19	2.86
NC	Il21r	NM_021887	Interleukin 21 receptor	1.63	1.21	1.04	2.85
Defense response	Cd180	NM_008533	Lymphocyte antigen 78	-1.40	1.32	2.41	2.85
Defense response	Clec2d	NM_053109	C-type lectin domain family 2	2.14	0.97	2.40	2.83
NC	Lair1	NM_178611	Leukocyte-associated Ig-like receptor	1.01	1.48	1.27	2.80
Type IIa hypersensitivity	Fcer1g	NM_010185	Fc receptor, IgE, high affinity I, gamma polypeptide	0.98	1.21	0.81	2.78
Signal transduction	Admr	NM_007412	Adrenomedullin receptor	1.38	0.61	0.84	2.71
Cell adhesion	Itgb2	NM_008404	Integrin beta 2	0.60	1.11	0.58	2.68
Signal transduction	Pilra	NM_153510	Paired immunoglobin-like type 2	1.20	2.17	1.38	2.64
Apoptosis	Traf1	NM_009421	Tnf receptor-associated factor 1	1.12	0.64	0.62	2.62
Signal transduction	Il15ra	NM_008358	Interleukin 15 receptor, alpha chain	1.29	0.77	1.52	2.60
Inflammatory response	Edg3	NM_010101	Sphingolipid g-protein-coupled receptor,	1.66	1.63	1.71	2.57
Signal transduction	Il10ra	NM_008348	Interleukin 10 receptor, alpha	0.72	1.06	0.89	2.55
NC	Paqr5	NM_028748	Progestin and adipoq receptor family member V	1.24	1.49	2.51	2.47
NC	Treml4	NM_172623	Triggering receptor expressed on myeloid cells-like 4	0.33	0.83	-0.69	2.45
Cell adhesion	Itgam	NM_008401	Integrin alpha M	0.66	0.71	1.60	2.44
Proteolysis	Arts1	NM_030711	Type 1 TNF receptor shedding aminopeptidase regulator	1.36	0.98	1.50	2.40
Signal transduction	Pik3ap1	NM_031376	Phosphoinositide-3-kinase adaptor protein 1	0.96	1.25	1.23	2.37
Inflammatory response	Tnfrsf1b	NM_011610	Tumor necrosis factor receptor superfamily, member 1b	0.56	0.47	0.39	2.31
Signal transduction	Il12rb1	NM_008353	Interleukin 12 receptor, beta 1	1.06	0.57	0.35	2.25
Chemotaxis	Ccr5	NM_009917	Chemokine (C-C motif) receptor 5	1.18	1.66	1.40	2.22
NC	Il2rg	NM_013563	Interleukin 2 receptor, gamma chain	1.28	0.43	-0.28	2.19
Inflammatory response	Cd14	NM_009841	Cd14 antigen	0.15	0.78	0.14	2.12
Proteolysis	Lnpep	NM_172827	Leucyl/cystinyl aminopeptidase	0.78	1.01	0.67	2.10
Immune response	Cd40	NM_170701	CD40 antigen	0.67	0.24	0.35	2.10
Cytokine & Chemokine signaling	Il2rb	NM_008368	Interleukin 2 receptor, beta chain	0.17	0.63	0.09	2.10

† Gene regulation was validated by Real time qRT-PCR.
Genes were considered significantly upregulated or downregulated if the change in their relative expression levels was ≥ 2 fold or ≤ -2 fold, respectively.
NC Not classified

Back to article page

ISSN: 1743-422X

Contact us

Submission enquiries: journalsubmissions@springernature.com